Applied Bioengineering

Innovations and Future Directions

; Jens Nielsen ; Gregory Stephanopoulos ; Toshiomi Yoshida (Redaktør)

A comprehensive overview of the topic, highlighting recent developments, ongoing research trends and future directions. Experts from Europe, Asia and the US cover five core areas of imminent importance to the food, feed, pharmaceutical and water treatment industries in terms of sustainable and innovative processing and production. Les mer
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Vår pris: 2616,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 21 dager

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A comprehensive overview of the topic, highlighting recent developments, ongoing research trends and future directions. Experts from Europe, Asia and the US cover five core areas of imminent importance to the food, feed, pharmaceutical and water treatment industries in terms of sustainable and innovative processing and production. In the field of enzyme engineering, they summarize historic developments and provide an overview of molecular enzyme engineering, while also discussing key principles of microbial process engineering, including chapters on process development and control. Further sections deal with animal and plant cell culture engineering. The final section of the book deals with environmental topics and highlights the application of bioengineering principles in waste treatment and the recovery of valuable resources. With its cutting-edge visions, extensive discussions and unique perspectives, this is a ready reference for biotechnologists, bioengineers, bioengineers, biotechnological institutes, and environmental chemists.

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Innholdsfortegnelse

List of Contributors XIX 1 Introduction 1 Toshiomi Yoshida 1.1 Introduction 1 1.2 Enzyme Technology 2 1.3 Microbial Process Engineering 2 1.4 Plant Cell Culture 5 1.5 Animal Cell Culture 5 1.6 Environmental Bioengineering 6 1.7 Composition of the Volume 7 References 7 Part I Enzyme Technology 11 2 Enzyme Technology: History and Current Trends 13 Klaus Buchholz and Uwe T. Bornscheuer 2.1 The Early Period up to 1890 13 2.2 The Period from 1890 to 1940 16 2.3 A New Biocatalyst Concept Immobilized Enzymes 19 2.4 Expanding Enzyme Application after the 1950s 24 2.5 Recombinant Technology A New Era in Biocatalysis and Enzyme Technology 27 2.6 Current Strategies for Biocatalyst Search and Tailor Design 32 2.7 Summary and Conclusions 39 Acknowledgment 40 Abbreviations 40 References 40 3 Molecular Engineering of Enzymes 47 Maria Elena Ortiz-Soto and Jurgen Seibel 3.1 Introduction 47 3.2 Protein Engineering: An Expanding Toolbox 48 3.3 High-Throughput Screening Systems 56 3.4 Engineered Enzymes for Improved Stability and Asymmetric Catalysis 58 3.5 De Novo Design of Catalysts: Novel Activities within Common Scaffolds 65 3.6 Conclusions 69 References 69 4 Biocatalytic Process Development 81 John M.Woodley 4.1 A Structured Approach to Biocatalytic Process Development 83 4.2 Process Metrics 83 4.3 Technologies for Implementation of Biocatalytic Processes 87 4.4 Industrial Development Examples 91 4.5 Future Outlook 95 4.6 Concluding Remarks 96 References 96 5 Development of Enzymatic Reactions in Miniaturized Reactors 99 Takeshi Honda, Hiroshi Yamaguchi, and Masaya Miyazaki 5.1 Introduction 99 5.2 Fundamental Techniques for Enzyme Immobilization 100 5.3 Novel Techniques for Enzyme Immobilization 150 5.4 Conclusions and Future Perspectives 155 Abbreviations 156 References 157 Part II Microbial Process Engineering 167 6 Bioreactor Development and Process Analytical Technology 169 Toshiomi Yoshida 6.1 Introduction 169 6.2 Bioreactor Development 170 6.3 Monitoring and Process Analytical Technology 196 6.4 Conclusion 203 Abbreviations 204 References 204 7 Omics-Integrated Approach for Metabolic State Analysis of Microbial Processes 213 Hiroshi Shimizu, Chikara Furusawa, Takashi Hirasawa, Katsunori Yoshikawa, Yoshihiro Toya, Tomokazu Shirai, and Fumio Matsuda 7.1 General Introduction 213 7.2 Transcriptome Analysis of Microbial Status in Bioprocesses 214 7.3 Analysis of Metabolic State Based on Simulation in a Genome-Scale Model 219 7.4 13C-Based Metabolic Flux Analysis of Microbial Processes 223 7.5 Comprehensive Phenotypic Analysis of Genes Associated with Stress Tolerance 227 7.6 Multi-Omics Analysis and Data Integration 230 7.7 Future Aspects for Developing the Field 231 Acknowledgments 233 References 233

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