Industrial Biotechnology

Microorganisms

; Jens Nielsen ; Gregory Stephanopoulos ; Christoph Wittmann (Redaktør) ; James C. Liao (Redaktør)

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Les mer
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Leveringstid: Sendes innen 21 dager

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The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book.
Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.

Fakta

Innholdsfortegnelse

List of Contributors XVII About the Series Editors XXIX Preface XXXI Part I Industrial Biotechnology: From Pioneers to Visionary 1 1 History of Industrial Biotechnology 3 Arnold L. Demain, Erick J. Vandamme, John Collins, and Klaus Buchholz 1.1 The Beginning of Industrial Microbiology 3 1.2 Primary Metabolites and Enzymes 7 1.3 The Antibiotic Era 16 1.4 The Biotechnology Era Between 1970 and 2015 27 1.5 How Pioneering Developments Led to Genetic Engineering 48 References 73 2 Synthetic Biology: An Emerging Approach for Strain Engineering 85 Jie Sun and Hal Alper 2.1 Introduction 85 2.2 Basic Elements 86 2.3 Functional and Robust Modules 96 2.4 Microbial Communities 102 2.5 Conclusions and Future Prospects 104 Acknowledgments 104 References 104 3 Toward Genome-Scale Metabolic Pathway Analysis 111 Jurgen Zanghellini, Matthias P. Gerstl, Michael Hanscho, Govind Nair, Georg Regensburger, Stefan Muller, and Christian Jungreuthmayer 3.1 Introduction 111 3.2 DD Method 114 3.3 Calculating Short EFMs in Genome-Scale Metabolic Networks 116 3.4 Conclusions 120 Acknowledgments 121 References 121 4 Cell-Free Synthetic Systems for Metabolic Engineering and Biosynthetic Pathway Prototyping 125 Ashty S. Karim, Quentin M. Dudley, and Michael C. Jewett 4.1 Introduction 125 4.2 Background 127 4.3 The Benefits of Cell-Free Systems 129 4.4 Challenges and Opportunities in Cell-Free Systems 135 4.5 Recent Advances 140 4.6 Summary 141 Acknowledgments 141 References 142 Part II Multipurpose Bacterial Cell Factories 149 5 Industrial Biotechnology: Escherichia coli as a Host 151 Matthew Theisen and James C. Liao 5.1 Introduction 151 5.2 E. coli Products 152 5.3 Rewiring Central Metabolism 165 5.4 Alternative Carbon Sources 167 5.5 E. coli Techniques and Concerns 169 5.6 Conclusions 170 References 171 6 Industrial Microorganisms: Corynebacterium glutamicum 183 Judith Becker and Christoph W