Immunotherapy in Translational Cancer Research

Laurence J. N. Cooper (Redaktør) ; Elizabeth A. Mittendorf (Redaktør) ; Judy Moyes (Redaktør) ; Sabitha Prabhakaran (Redaktør)

A guide to state-of-the-art cancer immunotherapy in translational cancer research


A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. Les mer
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Om boka

A guide to state-of-the-art cancer immunotherapy in translational cancer research


A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.


Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world's foremost cancer research and care center and:





Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care

Filled with the concepts, examples, and approaches for developing individualized therapy

Explores the breath of treatments that reflect the complexity of the immune system itself

Includes contributions from a panel international experts in the field of immunotherapy



Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Fakta

Innholdsfortegnelse

Editors vi


Contributors vii


Introduction ix


1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1
Saranya Chumsri and Keith L. Knutson


2 Monoclonal Antibody Therapy 12
Elizabeth A. Mittendorf and Sabitha Prabhakaran


3 Somatic Mutations and Immunotherapy 24
Eric Tran


4 Checkpoint Blockade 37
Tracy A. Proverbs?Singh Jedd Wolchok and Alexandra Snyder


5 Myeloid Leukemia Vaccines 54
Paul M. Armistead and Jonathan S. Serody


6 Cancer Vaccines for Solid Tumors 72
Timothy J. Vreeland Garth S. Herbert and George E. Peoples


7 Immunotherapy with Non-Genetically Modified T Cells 91
Cassian Yee


8 Immunotherapy with Genetically Modified T Cells 101
Liora Schultz and Crystal Mackall


9 Immunomodulation with Adjuvants and Cytokines 115
Dae won Kim and Adi Diab


10 Immune Cell Migration in Cancer and Immunotherapy 132
Timothy Murray and Daniel E. Speiser


11 Repurposing of Drugs for Immunotherapy 143
Jyothishmathi Swaminathan and Vidya Gopalakrishnan


12 Immunomodulation with Radiation 161
Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh


13 Good Manufacturing Practices Facilities for Cellular Therapy 177
Andrew D. Fesnak and Bruce L. Levine


14 T Cell Receptor Mimic Antibodies 186
Gheath Alatrash and Jeffrey J. Molldrem


15 Stem Cell Transplantation for Treatment of Malignancy 201
Lohith S. Bachegowda and Richard E. Champlin


16 Natural Killer Cell-Based Immunotherapy 215
Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee


17 Immunologic Monitoring in Immuno?Oncology 228
William R. Gwin and Mary L. Disis


18 Cell?Based Therapies for Canine Cancer 252
Nicola J. Mason and M. Kazim Panjwani


19 Interaction between Targeted Therapy and Immunotherapy 268
Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo


Index 286

Om forfatteren

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA.

Elizabeth A. Mittendorf, Pro