Skin Lymphoma

The Illustrated Guide

A complete guide to the diagnosis and management of cutaneous lymphomas and pseudolymphomas


Easily misdiagnosed as benign skin diseases, malignant cutaneous lymphomas can present a variety of challenges to trainees and practicing specialists alike. Les mer
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Om boka

A complete guide to the diagnosis and management of cutaneous lymphomas and pseudolymphomas


Easily misdiagnosed as benign skin diseases, malignant cutaneous lymphomas can present a variety of challenges to trainees and practicing specialists alike. Skin Lymphoma: The Illustrated Guide has been designed to alleviate some of these difficulties, providing all those working in the dermatological field with a complete and easily consulted text on this potentially fatal cancer. Authored by renowned dermatopathologist Professor Lorenzo Cerroni, its exhaustive contents cover the clinical presentations and pathological correlates of cutaneous lymphomas in their various forms, alongside their prognoses and strategies for treatment.


This expanded fifth edition features a wealth of enhancements and additions, including new chapters, updated content, and more than 1,300 full-color illustrations. Revised to reflect the most recent World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classifications, its cutting-edge approach to its subject incorporates the latest molecular data, alongside more familiar histopathological and clinical features. The book's considerable scope has been broadened into new and groundbreaking areas, the details of which are explored in chapters discussing primary cutaneous acral CD8+ T-cell lymphoma, composite lymphomas, and non-neoplastic cutaneous signs of systemic lymphomas, as well as in new sections on previously unexamined entities such as implant-associated anaplastic large cell lymphoma.





Fully updated with new genetic data and most recent WHO classifications

Contains four newly written chapters

Features unconventional presentation sections with commentary on diagnosis

Includes more than 1,300 color illustrations



Skin Lymphoma: The Illustrated Guide is an indispensable resource forclinical dermatologists, dermatopathologists, and any other medical practitioners and trainees involved in the diagnosis and treatment of skin lymphomas.

Fakta

Innholdsfortegnelse

List of Teaching Cases xi


Preface xiii


Acknowledgments xv


1 Introduction 1


Section 1: Cutaneous NK/T?Cell lymphomas


2 The ''parapsoriases'': A Riddle, Wrapped in a Mystery, Inside an Enigma 15


3 Mycosis Fungoides 23


4 Sezary Syndrome 113


5 Primary Cutaneous CD30+ Lymphoproliferative Disorders 133


Lymphomatoid Papulosis 134


Cutaneous Anaplastic Large Cell Lymphoma 150


"Borderline" Cases 167


Intralymphatic CD30+ Large T?Cell Lymphoma 168


Implant?Associated Anaplastic Large Cell Lymphoma 170


6 Subcutaneous Panniculitis?like T?cell Lymphoma 180


7 Aggressive Cutaneous Cytotoxic Lymphomas 195


Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T?Cell Lymphoma 196


Primary Cutaneous / T?Cell Lymphoma 201


Cutaneous Extranodal NK/T?Cell Lymphoma, Nasal Type 208


8 Cutaneous Peripheral T?cell Lymphoma, Not Otherwise Specified (NOS) 219


9 Cutaneous CD4+ Small/Medium T?cell Lymphoproliferative Disorder 228


10 Acral CD8+ Cutaneous T?cell Lymphoma 235


11 Cutaneous Adult T?cell Leukemia/Lymphoma 239


12 Other Cutaneous NK/T?cell Lymphomas 243


Cutaneous Angioimmunoblastic T?Cell Lymphoma 243


Hydroa Vacciniforme?Like Lymphoproliferative Disorder 246


Severe Mosquito Bite Allergy 250


Section 2: Cutaneous B?Cell lymphomas


13 Cutaneous Follicle Center Lymphoma 255


14 Cutaneous Marginal Zone Lymphoma (Cutaneous MALT Lymphoma) and Variants 274


Cutaneous Marginal Zone Lymphoma, Conventional Variant 276


Cutaneous Marginal Zone Lymphoma, Lymphoplasmacytic Variant 287


Cutaneous Marginal Zone Lymphoma, Plasmacytic Variant 290


Cutaneous Marginal Zone Lymphoma, Blastoid Variant 292


Cutaneous Amyloidoma 293


15 Cutaneous Diffuse Large B?cell Lymphoma, Leg Type 299


16 Intravascular Large Cell Lymphomas 315


Intravascular Large B?Cell Lymphoma 316


Intravascular Large NK/T?Cell Lymphoma 321


17 Other Cutaneous B?cell Lymphomas 326


Epstein-Barr Virus (EBV)?Positive Cutaneous Diffuse Large B?Cell Lymphoma, Not Otherwise Specified (NOS) 326


Specific Cutaneous Manifestations in Mantle Cell Lymphoma 329


Specific Cutaneous Manifestations in Extracavitary Primary Effusion Lymphoma 331


Specific Cutaneous Manifestations in Multiple Myeloma 334


Specific Cutaneous Manifestations in Burkitt Lymphoma 336


Cutaneous Lymphomatoid Granulomatosis 340


Cutaneous Plasmablastic Lymphoma 342


Cutaneous T?Cell/Histiocyte?Rich Large B?Cell Lymphoma 344


Cutaneous Manifestations in Waldenstrom Macroglobulinemia 346


Epstein-Barr Virus (EBV)?Associated Mucocutaneous Ulcers 347


Section 3: Cutaneous lymphomas in immunosuppressed individuals


18 Cutaneous Lymphomas in Immunosuppressed Individuals 357


Cutaneous Posttransplant Lymphoproliferative Disorders 358


Cutaneous Lymphomas in HIV?Infected Individuals 365


Cutaneous Lymphoproliferative Disorders in Other Iatrogenic and Non?Iatrogenic Immune Deficiencies 368


Section 4: Specific cutaneous manifestations of leukemias and of precursor hematologic neoplasms


19 Cutaneous Manifestations of B?cell Chronic Lymphocytic Leukemia 379


Progression to Diffuse Large B?Cell Lymphoma (Richter Syndrome) 385


20 Cutaneous Manifestations of Myelogenous Leukemia 390


Chronic Myeloid Leukemia 399


Myelodysplastic Syndromes 400


21 Blastic Plasmacytoid Dendritic Cell Neoplasm 407


Mature Plasmacytoid Dendritic Cell Proliferations Associated With Myeloid Neoplasms 415


22 Cutaneous Manifestations of Other Leukemias 419


T?Cell Prolymphocytic Leukemia 419


Aggressive Natural Killer Cell Leukemia 421


Specific Skin Manifestations of Other Types of Leukemia 422


23 Cutaneous Lymphoblastic Lymphomas 424


Cutaneous B?Lymphoblastic Lymphoma 424


Cutaneous T?Lymphoblastic Lymphoma 428


Section 5: Cutaneous manifestations of other lymphomas and non?neoplastic cutaneous signs of systemic lymphomas


24 Cutaneous Manifestations of Hodgkin Lymphoma 437


Primary Cutaneous Hodgkin Lymphoma 440


25 Cutaneous Composite Lymphomas 443


26 Nonneoplastic Cutaneous Signs of Systemic Lymphomas 450


Section 6: Cutaneous lymphomas in children and adolescents


27 Cutaneous Lymphomas in Children and Adolescents 463


Mycosis Fungoides 463


Sezary Syndrome 464


Lymphomatoid Papulosis 467


Cutaneous Anaplastic Large Cell Lymphoma 467


Subcutaneous Panniculitis?Like T?Cell Lymphoma 468


Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T?Cell Lymphoma 468


Primary Cutaneous / T?Cell Lymphoma 468


Extranodal NK/T?Cell Lymphoma, Nasal Type 468


Primary Cutaneous Peripheral T?Cell Lymphoma, not Otherwise Specified (NOS) 468


Cutaneous CD4+ Small/Medium T?Cell Lymphoproliferative Disorder 468


Cutaneous Angioimmunoblastic T?Cell Lymphoma 468


Epstein-Barr Virus (EBV)?Positive T?Cell and NK?Cell Lymphoproliferative Diseases of Childhood (Hydroa Vacciniforme?Like Lymphoproliferative Disorder, Severe Mosquito Bite Allergy) 468


Adult T?Cell Lymphoma/Leukemia 469


Acral CD8+ T?Cell Lymphoma 469


Cutaneous Follicle Center Lymphoma 469


Cutaneous Marginal Zone Lymphoma (Cutaneous MALT Lymphoma) 469


Cutaneous Burkitt Lymphoma 469


Cutaneous Intravascular Large Cell Lymphoma 469


Cutaneous Lymphomatoid Granulomatosis 469


EBV+ Mucocutaneous Ulcer 469


Cutaneous Lymphomas in Immunosuppressed Children and Adolescents 469


Cutaneous Manifestations of Myelogenous Leukemia 469


Blastic Plasmacytoid Dendritic Cell Neoplasm 470


Cutaneous Lymphoblastic Lymphoma (B or T Cell) 470


Section 7: Pseudolymphomas of the skin


28 Pseudolymphomas of the Skin 475


Chronic Actinic Dermatitis (Actinic Reticuloid) 477


Lymphomatoid Contact Dermatitis 478


Non?mycosis Fungoides?associated Follicular Mucinosis and Other Mimickers of Pilotropic Mycosis Fungoides 479


Solitary Idiopathic B/T?cell Pseudolymphoma 481


Lichenoid (Lymphomatoid) Keratosis 483


T?cell?Rich Angiomatoid Polypoid Pseudolymphoma/ Acral Pseudolymphomatous Angiokeratoma in Children/ Pretibial Lymphoplasmacytic Plaque in Children ("T/B?cell Angiomatoid Pseudolymphoma") 486


Lichen Aureus/Lichenoid Pigmented Purpuric Dermatitis 487


Lichen Sclerosus 489


Vitiligo 489


Annular Lichenoid Dermatitis of Youth 490


Pseudolymphomatous Acrodermatitis Chronica Atrophicans 493


Pseudolymphomatous Atopic Dermatitis 495


Nonneoplastic Erythroderma in Adult Patients 496


Pseudolymphomatous Cutaneous Infiltrates in Human Immunodeficiency Virus (HIV)?Infected Patients and in Other Immune Deficiencies 499


CD30+ T?cell Pseudolymphomas 502


Persistent Nodular Arthropod Bite Reactions and Nodular Scabies 502


Pseudolymphomas in Herpes Simplex and Herpes Zoster Infections 504


Hydroa Vacciniforme 506


Pityriasis Lichenoides 507


Pseudolymphomas Associated with Lupus Erythematosus 511


Lymphomatoid Drug Reactions 515


Lymphocytoma Cutis 516


Lymphocytoma Cutis Associated with Borrelia Infection 518


Pseudolymphomas at Sites of Vaccination 522


Pseudolymphomas in Tattoos 524


Localized Scleroderma/Morphea 524


Cutaneous IgG4?Related Disease 526


Pseudolymphomas in Syphilis 529


Cutaneous Plasma Cell Granuloma 534


Cutaneous and Systemic Plasmacytosis 535


Cutaneous Manifestations of Castleman Disease 536


Cutaneous Extramedullary Hematopoiesis 537


Histiocytoid Sweet Syndrome 538


Intralymphatic Histiocytosis 539


Benign Intralymphatic Proliferation of T?cell Lymphoid Blasts 541


Other "Accidental" Pseudolymphomas 543


"Malignant" Pseudolymphomas 546


Section 8: The cutaneous "atypical lymphoid proliferation"


29 The Cutaneous "Atypical Lymphoid Proliferation" 565


Index 569

Om forfatteren

LORENZO CERRONI, MD, is Professor of Dermatology and Venereology and Director of the Dermatopathology Research Center at the Medical University of Graz, Graz, Austria.