Toxicologic Pathology for Non-Pathologists

Thomas J. Steinbach (Redaktør) ; Daniel J. Patrick (Redaktør) ; Mary Ellen Cosenza (Redaktør)

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. Les mer
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Innbundet
Vår pris: 3713,-

(Innbundet) Fri frakt!
Leveringstid: Ikke i salg
På grunn av Brexit-tilpasninger og tiltak for å begrense covid-19 kan det dessverre oppstå forsinket levering.

Om boka

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances.
Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Fakta

Innholdsfortegnelse

1. Introduction to Toxicologic Pathology



George A. Parker







2. The Pathology Report, Peer Review, and Pathology Working Group



Ted A. Birkebak and Peter C. Mann







3. Routine and Special Techniques in Toxicologic Pathology



Pamela Blackshear, Erica Carroll, Sasmita Mishra, Matthew Renninger, and Arun Tatiparthi







4. Pathology of the Liver and Gallbladder



Robert R. Maronpot and David E. Malarkey







5. Pathology of the Gastrointestinal Tract and Exocrine Pancreas



Mark J. Hoenerhoff and Arun Kumar R. Pandiri







6. Pathology of the Urinary System



Kendall S. Frazier







7. Pathology of the Nervous System



Juliana S. Lee, Sarah D. Cramer, and Mark T. Butt







8. Pathology of the Cardiovascular System



Joshua H. Decker, Radhakrishna Sura, and Paul W. Snyder







9. Pathology of the Respiratory System



Jack R. Harkema and James G. Wagner







10. Pathology of the Lymphoid System



Tracey L. Papenfuss, Marlon C. Rebelatto, and Brad Bolon







11. Pathology of the Male and Female Reproductive System and Mammary Gland



Justin D. Vidal







12. Pathology of the Integumentary System



Kelly L. Diegel







13. Pathology of the Endocrine System



Brent E. Walling and Thomas J. Rosol







14. Pathology of Bone, Skeletal Muscle, and Tooth



Stacey Fossey, D. Greg Hall, Andrew Suttie, Martin Guillot, and Aurore Varela







15. Pathology of the Eye



Leandro B.C. Teixeira







16. Pathology of the Ear



Kenneth A. Schafer







17. Principles of Toxicologic Clinical Pathology



Adam Aulbach and Laura Cregar







18. Carcinogenicity



Paul Howroyd







19. Pathology of Juvenile Animals



Catherine A. Picut and Amera K. Remick







20. Non-Mammalian Laboratory Species: Fish, Frogs, and Beyond



Shannon Wallace and Jeff Wolf











Appendix: Fundamental Pathology Terminology Based on the Standard for the Exchange of Nonclinical Data (SEND)

Om forfatteren

Thomas J. Steinbach DVM, DACVP, DABT (Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA) and Daniel J. Patrick DVM, DACVP, DABT (Charles River Laboratories, Inc., Mattawan, MI, USA) have worked for numerous years to help organize the successful "Pathology for Non-Pathologists" short course, created with the support of the American College of Toxicology (ACT) and Society of Toxicologic Pathology (STP), upon which this book is based. Mary Ellen Cosenza PhD, DABT, RAC, ATS (MEC Regulatory & Toxicology Consulting, LL