This thesis addresses computation fluid dynamics modelling of aortic dissection (AD), in order to generate in silico diagnostic
information and assess `virtual surgery' outcomes. The thesis introduces several important advances in the modelling of aortic
dissection and lays essential groundwork for further development of this technology. The work thesis represents a unique and
major step forward in our understanding of AD using a patient-specific, systematic and coherent simulation approach, and is
currently the most advanced work available on AD.