The book bridges the gap between mass spectrometry and supramolecular chemistry, which until now were commonly deemed incompatible. The coverage resolves points of error and misinterpretation that have plagued the use of mass spectrometry in supramolecular chemistry. It provides a brief introduction to mass spectrometry and supramolecular chemistry in order to orient the audience. The text also offers supramolecular chemists a detailed introduction to mass spectrometric methodology, and identifies chemical questions that mass spectrometry can answer, citing illustrative examples and discussing them in detail.