Targeting the DNA Damage Response for Anti-Cancer Therapy
«“The book provides up to date and comprehensive review of hot topic in the field cancer drug discovery and development and represents a promising therapeutic strategy for cancer patients. It is the source of valuable information for people working in science and oncology clinics.” (Jela Brozmanova, Neoplasma, Vol. 65 (06), 2018)»
Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. Les mer
In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.
Detaljer
- Forlag
- Birkhauser Verlag AG
- Innbinding
- Innbundet
- Språk
- Engelsk
- Sider
- 401
- ISBN
- 9783319758343
- Utgivelsesår
- 2018
- Format
- 24 x 16 cm
Anmeldelser
«“The book provides up to date and comprehensive review of hot topic in the field cancer drug discovery and development and represents a promising therapeutic strategy for cancer patients. It is the source of valuable information for people working in science and oncology clinics.” (Jela Brozmanova, Neoplasma, Vol. 65 (06), 2018)»