Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability,
they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical
and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety
of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists
in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide
range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show
chiral intermediates and other by-products for each reaction-including hydrolytic, acylation, halogenation, esterification,
dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C-C, C-N, C-O bonds formation.
Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering
of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating
novel molecules by combinatorial biocatalysis and high-throughput screening.
Focusing on industrial applications,
the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization,
reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases
the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.