Handbook of Venoms and Toxins of Reptiles

Stephen P. Mackessy (Redaktør)

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. Les mer
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Om boka

A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation.


This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.

Fakta

Innholdsfortegnelse

Preface


About the Editor


Contributors





Section I: Introduction and Technologies Used in Toxinology


1. Reptile venoms and toxins: Unlimited opportunities for basic and applied research - Stephen P. Mackessy


2. Present and future of snake venom proteomics profiling - Juan J. Calvete and Bruno Lomonte


3. Applications of genomics and related technologies for studying reptile venoms - Drew R. Schield, Blair W. Perry, Giulia I.M. Pasquesi, Richard W. Orton, Zachary L. Nikolakis, Aundrea K. Westfall, Todd A. Castoe


4. Snake venom gland transcriptomics - Cassandra M. Modahl and Rajeev Kungur Brahma


5. X-ray crystallography and structural studies of toxins - Vinicius Lucatelle da Silva, Ricardo Barros Mariutti, Monika Aparecida Coronado, Raphael Josef Eberle, Fabio Rogerio de Moraes and Raghuvir Krishnaswamy Arni


6. Envenomations and Treatment: Translating between the bench and the bedside - Nicklaus Brandehoff and Jordan Benjamin


7. Current assessment of the state of snake venom toxinological research with a view to the future - Sarah Natalie Cirilo Gimenes and Jay W. Fox





Section II: Venom Gland Structure, Systematics and Ecology


8. Reptile venom glands: Form, function, future, concepts and controversies - Scott A. Weinstein


9. Advances in venomous snake systematics, 2009-2019 - Wolfgang Wuster


10. Biochemical ecology of venomous snakes - Cara F. Smith and Stephen P. Mackessy


11. Resistance of native species to reptile venoms -- Danielle H. Drabeck





Section III: Reptile Venom Non-enzymatic Toxins


12. Three-finger toxins - Rajeev Kungur Brahma, Cassandra M. Modahl and


R. Manjunatha Kini


13. Myotoxin a, crotamine and defensin homologs in reptile venoms - Lucas C. Porta, Pedro Z. Amaral, Paulo Z. Amaral and Mirian A. F. Hayashi


14. Reptile venom disintegrins - Anthony J. Saviola and Juan J. Calvete


15. Reptile venom cysteine-rich secretory proteins - Maria Elisa Peichoto and Marcelo Larami Santoro


16. Bradykinin-potentiating and related peptides from reptile venoms - Daniel Carvalho Pimenta and Patrick Jack Spencer


17. Exendins and its related proteins - Michelle Khai Khun Yap and Nurhamimah Misuan


18. Reptile venom C-type-lectins - Kenneth J. Clemetson


19. Snake venom Kunitz-type inhibitors and cystatins - structure and function - Elda E. Sanchez, Emelyn Salazar, Montamas Suntravat and Francisco Torres


20. Small molecular constituents of snake venoms - Alejandro Villar-Briones and Steven D. Aird


21. Cobra venom factor: Structure, function, biology, research tool and drug lead - Carl-Wilhelm Vogel, Brian E. Hew and David C. Fritzinger


22. Snake toxins targeting diverse ion channels - Matan Geron and Avi Priel





Section IV: Reptile Venom Enzyme Toxins


23. Thrombin-like serine proteinases in reptile venoms - Stephen D. Swenson, Samantha Stack


and Francis S. Markland Jr.


24. Snake venom metalloproteinases - Charlotte A. Dawson, Stuart Ainsworth, Laura-Oana Albulescu and Nicholas R. Casewell


25. Snake venom matrix metalloproteinases (svMMPs): Alternative proteolytic enzymes in rear-fanged snake venoms - Inacio L. M. Junqueira-de-Azevedo and Juan David Bayona-Serrano


26. Snake venom phospholipase A2 toxins - Bruno Lomonte and Igor Krizaj


27. Reptile venom L-amino acid oxidases - structure and function - Juliana P. Zuliania, Mauro V. Paloschi, Adriana S. Pontes, Charles N. Boeno, Jessica A. Lopes, Sulamita S. Setubal, Fernando B. Zanchi and Andreimar M. Soares


28. Snake venom nucleases, nucleotidases, and phosphomonoesterases - Juri Siigur and Ene Siigur


29. Reptile venom acetylcholinesterases - Mushtaq Ahmed, Wasim Ahmad, Nadia Mushtaq,


Rehmat Ali Khan and Maria Rosa Chitolina Schetinger


30. Inhibitors of reptile venom toxins - Ana F. Gomez Garay, Jorge J. Alfonso, Anderson M. Kayano, Juliana C. Sobrinho, Cleopatra A. S. Caldeira, Rafaela Diniz-Sousa, Fernando B. Zanchi, Juliana P. Zuliani, and Andreimar M. Soares





Section V: Global Approaches to Envenomations and Treatments


31. Snakebite envenomation as a neglected tropical disease: new impetus for confronting an old scourge - Jose Maria Gutierrez


32. Current industrial production of snake antivenoms - Mariangela Vargas, Melvin Sanchez, Andres Hernandez, Aaron Gomez, Mauricio Arguedas, Andres Sanchez, Laura Sanchez, Mauren Villalta, Maria Herrera and Alvaro Segura


33. Antivenom in the age of recombinant DNA technology - Andreas H. Laustsen


34. Epidemiology and treatment of reptile envenomations in the United States - Daniel E. Keyler and Nicklaus Brandehoff


35. Envenomations by reptiles in Mexico - Edgar Neri-Castro, Melisa Benard-Valle, Jorge Lopez de Leon, Leslie Boyer and Alejandro Alagon


36. Snakebite envenomation in Central America: Epidemiology, pathophysiology and treatment - Jose Maria Gutierrez


37. Snakebite in Southeast Asia: Envenomation and clinical management- Nget Hong Tan, Kae Yi Tan and Choo Hock Tan


38. Snake envenomation: Therapy and challenges in India - Ashis K. Mukherjee, Bhargab Kalita, Sumita Dutta, Aparup Patra, Chitta R. Maiti and Dileep Punde


39. Snakebite in Africa: Current situation and urgent needs - Jean-Philippe Chippaux


40. Approaches to snake envenomation in Southern Africa - James Pattinson, George Oosthuizen, Colin R. Tilbury and Darryl Wood





Section VI: Reptile Venoms - Production and as a Source of Therapeutics


41. Large-scale snake colonies for venom production: Considerations and challenges - Kristen L. Wiley and James R. Harrison


42. Toxins to drugs - biochemistry and pharmacology - Zoltan Takacs


Om forfatteren

Stephen P. Mackessy is Professor of Biology in the School of Biological Sciences at the University of Northern Colorado (UNC). His research broadly encompasses the biology of venomous snakes and the biochemistry of snake venoms, and he has published over one hundred scientific papers, book chapters, and natural history notes.