Haematology

From the Image to the Diagnosis

; Barbara J. Bain

Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. Les mer
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Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis.


Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct?descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work.


Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.
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Forlag: Wiley-Blackwell
Innbinding: Innbundet
Språk: Engelsk
ISBN: 9781119777502
Format: 26 x 18 cm
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Preface


Abbreviations


1. Haemophagocytic syndrome secondary to anaplastic large cell lymphoma


2. Bone marrow AL amyloidosis


3. Cup-like blast morphology in acute myeloid leukaemia


4. Neutrophil morphology


5. Primary myelofibrosis


6. Sarcoidosis


7. Leishmaniasis


8. Gelatinous transformation of the bone marrow


9. Acanthocytic red cell disorders


10. Large granular lymphocytic leukaemia


11. Pure erythroid leukaemia


12. Reactive mesothelial cells


13. Plasmablastic myeloma


14. Septicaemia


15. Unstable haemoglobin (haemoglobin Koeln) and a myeloproliferative neoplasm


16. Sickle cell anaemia in crisis


17. Acute myeloid leukaemia with t(8;21)(q22;q22.1)


18. Chronic neutrophilic leukaemia


19. Essential thrombocythaemia


20. Hairy cell leukaemia


21. Mantle cell lymphoma in leukaemic phase


22. Infantile osteopetrosis


23. Reactive eosinophilia


24. Stomatocytic red cell disorders


25. Reactive lymphocytosis due to viral infection


26. Therapy-related acute myeloid leukaemia with eosinophilia


27. Red cell fragmentation syndromes


28. NK/T-cell lymphoma in leukaemic phase


29. Myelodysplastic syndrome with del(5q)


30. Classical Hodgkin lymphoma


31. Cryoglobulinaemia


32. Congenital dyserythropoietic anaemia


33. Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3)


34. Chronic myeloid leukaemia presenting with myeloid sarcoma and extreme thrombocytosis


35. Glucose-6-phosphate dehydrogenase deficiency


36. Leukaemic presentation of hepatosplenic gamma-delta T-cell lymphoma


37. Myelodysplastic syndromes


38. Pelger-Huet anomaly


39. Russell bodies in lymphoplasmacytic lymphoma


40. T-cell prolymphocytic leukaemia


41. Myeloid maturation arrest


42. MDS/MPN with ring sideroblasts and thrombocytosis


43. Acute myeloid leukaemia with inv(16)(p13.1q22)


44. Babesiosis


45. Haemoglobin E disorders


46. Juvenile myelomonocytic leukaemia


47. Non-haemopoietic tumours


48. Richter transformation of chronic lymphocytic leukaemia


49. Sickle cell-haemoglobin C disease


50. T cell/histiocyte-rich B-cell lymphoma


51. Miliary tuberculosis


52. Pure red cell aplasia


53. Lymphoblastic transformation of follicular lymphoma


54. Primary hyperparathyroidism


55. Gamma heavy chain disease


56. Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2)


57. AA amyloidosis


58. Acquired sideroblastic anaemia


59. Diffuse large B-cell lymphoma


60. Hickman line infection


61. Monocytes and their precursors


62. Paroxysmal cold haemoglobinuria


63. Transient abnormal myelopoiesis


64. Systemic lupus erythematosus


65. Granular blast cells in acute lymphoblastic leukaemia


66. Chronic myelomonocytic leukaemia


67. Burkitt lymphoma/leukaemia


68. Gaucher's disease


69. Myelodysplastic syndrome with haemophagocytosis


70. Primary oxalosis


71. Acute myeloid leukaemia with inv(3)(q21.3q26.2)


72. Autoimmune haemolytic anaemia


73. Chronic eosinophilic leukaemia due to FIP1L1-PDGFRA fusion gene


74. Leukaemic phase of follicular lymphoma


75. Megaloblastic anaemia


76. Reactive bone marrow and an abnormal PET scan


77. Acute megakaryoblastic leukaemia


78. Erythrophagocytosis and haemophagocytosis


79. Hyposplenism


80. Acquired haemoglobin H disease


81. Cystinosis


82. Familial platelet disorder with a predisposition to AML


83. Nodular lymphocyte predominant Hodgkin lymphoma


84. Acute monocytic leukaemia with NPM1 mutation


85. Adult T-cell leukaemia/lymphoma


86. Hereditary elliptocytosis and pyropoikilocytosis


87. Sezary syndrome


88. Spherocytic red cell disorders


89. Acute myeloid leukaemia and metastatic carcinoma


90. Chediak-Higashi syndrome


91. Cortical T-lymphoblastic leukaemia/lymphoma


92. Trypanosomiasis


93. Acute myeloid leukaemia with myelodysplasia-related changes


94. Blastic plasmacytoid dendritic cell neoplasm


95. Inherited macrothrombocytopenias


96. Persistent polyclonal B-cell lymphocytosis


97. Acute myeloid leukaemia with t(6;9)(p23;q34.1)


98. B-cell prolymphocytic leukaemia


99. Various red cell enzyme disorders


100. Sea blue histiocytosis in multiple myeloma


101. Enteropathy-associated T-cell lymphoma


Answers to multiple choice questions and further reflections on the theme


Index