This book gathers selected contributions presented at the INdAM Workshop "DREAMS", held in Rome, Italy on January 22 26, 2018. Addressing cutting-edge research topics and advances in computer aided geometric design and isogeometric analysis, it covers distinguishing curve/surface constructions and spline models, with a special focus on emerging adaptive spline constructions, fundamental spline theory and related algorithms, as well as various aspects of isogeometric methods, e.g. efficient quadrature rules and spectral analysis for isogeometric B-spline discretizations. Applications in finite element and boundary element methods are also discussed. Given its scope, the book will be of interest to both researchers and graduate students working in these areas.