Radiopharmaceuticals
«
This high-quality hardcover volume is a textbook providing an exposition … on the development and evaluation of antibody-based and other targeted radionuclide therapies … unique in the targeted radionuclide therapy literature.
—Medical Physics, May 2012The book covers a very important topic and fills a gap not covered by others. I believe that it will be a very valuable in our education of Ph.D. students and also very valuable for researchers in this area. I will recommend the book to my colleagues.
—Professor Sven-Erik Strand, University of LundThe reader is taken on a journey to discover radiopharmaceutical evaluation and dose estimation. The various chapters cover all aspects of radiopharmaceutical development (tumor targeting, preclinical development, selection of radiopharmaceuticals for clinical trials, etc). Chapters dedicated to dosimetry go beyond the usual discussion to cover aspects more related to pharmacokinetics assessment (modeling and temporal integration). Of particular interest are the chapters dedicated to absorbed dose/effect correlation. This is very relevant, especially since recent publications indicate that, in the context of molecular radiotherapy, if the biological end-point is clearly defined and the dosimetric approach is carried out in a rational way, absorbed dose (or derivates) will correlate with observed toxicity or efficacy.
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The book is written in a very clear style, and is accessible not only to physicists, but to any professional involved in radiopharmaceutical development and clinical or preclinical experiments. All chapters end with a summary that recapitulates the important points addressed in the chapter, and this a very helpful feature of this book.
Through 30 years of experience, Prof. Williams shares with us ideas, caveats, and hints applicable to the domain. In the acknowledgements, he indicates his will to ‘put some chips back in the pot.’ This is exactly how I receive this book: a senior scientist in our field is sharing his experience—and I dare say his wisdom—with us. This atypical book is going to be an essential part of my library.
—Manuel Bardies, Director of Research, INSERM
Nanoengineering, energized by the desire to find specific targeting agents, is leading to dramatic acceleration in novel drug design. However, in this flurry of activity, some issues may be overlooked. Les mer
Offering the unique perspective of a medical physicist who has worked directly with cancer patients for over three decades, Radiopharmaceuticals: Introduction to Drug Evaluation and Dose Estimation starts by exploring the recent history and current state of the field. Then, citing key research and practical examples, the author looks at how to run studies and employ estimation and evaluation methods that lead to the best multiple agents with the least amount of trial and error. He discusses methods that will allow researchers to more rigorously:
Differentiate one radiopharmaceutical (RP) from another
Estimate radiation doses
Correlate results across various species to realize more informed data from clinical trials
Incorporating developments in nanotechnology and radiology, with the ultimate goal of achieving personalized patient-specific treatment, this book crosses disciplines to addresses a range of topics including:
Preclinical RP development
Organization of clinical trials
Determination of activity in vivo
Modeling and temporal integration with a look at the mass law for tumor uptake as a function of tumor size (discovered by the author)
Absorbed dose estimates with and without clinical correlations
Multiple-modality therapy
Dr. Lawrence Williams has devoted most of his life's research to tumor detection and treatment, and his discoveries continue to influence evolving therapies. As s a medical physicist, he is eminently qualified to bring unique insight into the discussion of radiopharmaceutical dosage rates and efficacy.
Detaljer
- Forlag
- CRC Press
- Innbinding
- Paperback
- Språk
- Engelsk
- Sider
- 326
- ISBN
- 9780367577056
- Utgivelsesår
- 2020
- Format
- 23 x 16 cm
Anmeldelser
«
This high-quality hardcover volume is a textbook providing an exposition … on the development and evaluation of antibody-based and other targeted radionuclide therapies … unique in the targeted radionuclide therapy literature.
—Medical Physics, May 2012The book covers a very important topic and fills a gap not covered by others. I believe that it will be a very valuable in our education of Ph.D. students and also very valuable for researchers in this area. I will recommend the book to my colleagues.
—Professor Sven-Erik Strand, University of LundThe reader is taken on a journey to discover radiopharmaceutical evaluation and dose estimation. The various chapters cover all aspects of radiopharmaceutical development (tumor targeting, preclinical development, selection of radiopharmaceuticals for clinical trials, etc). Chapters dedicated to dosimetry go beyond the usual discussion to cover aspects more related to pharmacokinetics assessment (modeling and temporal integration). Of particular interest are the chapters dedicated to absorbed dose/effect correlation. This is very relevant, especially since recent publications indicate that, in the context of molecular radiotherapy, if the biological end-point is clearly defined and the dosimetric approach is carried out in a rational way, absorbed dose (or derivates) will correlate with observed toxicity or efficacy.
»
The book is written in a very clear style, and is accessible not only to physicists, but to any professional involved in radiopharmaceutical development and clinical or preclinical experiments. All chapters end with a summary that recapitulates the important points addressed in the chapter, and this a very helpful feature of this book.
Through 30 years of experience, Prof. Williams shares with us ideas, caveats, and hints applicable to the domain. In the acknowledgements, he indicates his will to ‘put some chips back in the pot.’ This is exactly how I receive this book: a senior scientist in our field is sharing his experience—and I dare say his wisdom—with us. This atypical book is going to be an essential part of my library.
—Manuel Bardies, Director of Research, INSERM