Necrotizing Enterocolitis

pathogenesis, diagnosis and treatment

David J. Hackam (Redaktør)

This is the first textbook devoted entirely to understanding and treating necrotizing enterocolitis (NEC), one of the leading causes of death and disability in premature infants. NEC continues to occur in neonatal units across the world, and the overall mortality has remained stubbornly high since its first description decades ago. Les mer
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Vår pris: 2025,-

(Innbundet) Fri frakt!
Leveringstid: Sendes innen 7 virkedager

Om boka

This is the first textbook devoted entirely to understanding and treating necrotizing enterocolitis (NEC), one of the leading causes of death and disability in premature infants. NEC continues to occur in neonatal units across the world, and the overall mortality has remained stubbornly high since its first description decades ago. Despite significant research into NEC, and a greater understanding of its underlying causes, there is no single source of information to which the care team can turn for guidance. This book fills that important gap in clinical care.


In selecting the topics for this inaugural textbook, three guiding principles have been followed. First, to include chapters that provide detailed information for the medical team - the doctors and nurses, the therapists and pharmacists, the chaplains and the child life workers - so that each team member can optimally recognize, prevent and treat patients with this disease. Second, to ensure that chapters cover the depth and breadth of the latest clinical and scientific research into NEC, each selected to identify specific preventative strategies or therapies for this disease. Third, and perhaps most importantly, to focus not only on the child with NEC, but also on the child's family, in order to provide comprehensive information about a disease that families have barely heard about, until the jarring day when their precious infant is affected by it.


This book therefore:








serves as a "how-to guide" for the care of the infant with NEC







summarises critical new research and offers guidelines for future key research areas







addresses the complex and difficult issues surrounding care of the critically ill infant suffering from NEC





Written for the entire health care team including paediatric surgeons, neonatologists, developmental paediatricians, epidemiologists, ethicists, child life professionals, therapists and specialist nurses, each team member will find this book of value. This book was written to demystify this cruel disease, and to unlock its closely held secrets of pathogenesis, diagnosis, treatment and prevention.

Fakta

Innholdsfortegnelse

List of Contributors


1. Introduction: Necrotizing Enterocolitis, The Stories of Its Tiny Patients, and the Journey Ahead


David J. Hackam


2. Nursing Considerations in Necrotizing Enterocolitis: Management of Infant Stomas


Margaret Birdsong and Michelle Felix


3. Nursing Considerations in Necrotizing Enterocolitis: Management of Central Venous Catheters


Margaret Birdsong and Michelle Felix


4. An Updated Overview of the Medical Management of Necrotizing Enterocolitis


Lila S. Nolan, Martin Goree, and Misty Good


5. Clinical Clues, Biochemical Indices, and Biomarkers: Diagnostic Considerations in Necrotizing Enterocolitis


Karl G. Sylvester and Enrico Danzer


6. Imaging Considerations in NEC Diagnosis: Plain Films, Ultrasound, and Everything Else


Emily A. Dunn


7. Spontaneous Intestinal Perforation (SIP) Is Not Necrotizing Enterocolitis but Remains the Major Confounder of NEC Data


Phillip V. Gordon, Jonathan R. Swanson, and Reese H. Clark


8. International Practice Patterns in NEC Management: North America, Europe, and Australasia


Maarten Janssen Lok, Carlos Zozaya, Sinobol Chusilp, and Agostino Pierro


9. Feeding Strategies in the Patient with Necrotizing Enterocolitis


Krista E. Cooksey, Olivia B. Parks, Angela N. Lewis, and Misty Good


10. Surgery for Necrotizing Enterocolitis: Indications, Techniques, and Outcomes


David J. Hackam


11. Major Issues Related to Progress in NEC


Josef Neu


12. Probiotics in the Prevention of Necrotizing Enterocolitis


Mark A. Underwood


13. Cardiovascular, Hemodynamic, and Critical Care Considerations in the Patient with Necrotizing Enterocolitis


Christine M. Cortelyou, Zachary A. Vesoulis, and Misty Good


14. Neurodevelopmental Considerations in the Patient with Necrotizing Enterocolitis


Panagiotis Kratimenos and Frances J. Northington


15. Lung Disease and Ventilator Strategies in Necrotizing Enterocolitis


Jegen Kandasamy and Namasivayam Ambalavanan


16. Clinical Trials in NEC Research: Advances, Perils, and Pitfalls


Cheryl Battersby, Chris Gale, and Neena Modi


17. Management of Short Bowel Syndrome after Necrotizing Enterocolitis


Ross Beckman and Samuel Alaish


18. Necrotizing Enterocolitis in Unusual Cases: Term Infants, Congenital Anomalies, and Comorbidities


Spencer W. Beasley


19. Intestinal Transplantation for Necrotizing Enterocolitis


Geoffrey Bond


20. Optical Spectroscopy for the Detection of Necrotizing Enterocolitis


Seth D. Goldstein


21. Anesthetic Management of the Neonate with Necrotizing Enterocolitis


John J. McCloskey


22. Novel and Alternative Techniques in Surgery for Necrotizing Enterocolitis


Maame Efua S. Sampah and David J. Hackam


23. Supporting NEC Risk Awareness with Bedside Tools Like GutCheckNEC


Sheila M. Gephart


24. Health Economics and Care Delivery Issues in Necrotizing Enterocolitis


Meredith E. Mowitz and John A. F. Zupancic


25. Quality Improvement and Necrotizing Enterocolitis


Minesh Khashu and Sunitha Vimalesvaran


26. Implementation Strategies for Quality Improvement to Avoid Necrotizing Enterocolitis


Sheila M. Gephart


27. Clinical Outcomes in Children with NEC


Mark D. Stringer


28. Contextualizing Necrotizing Enterocolitis within Health Disparities Research


Amaris M. Keiser


29. Ethical Issues in the Care of Children with Necrotizing Enterocolitis


Margaret R. Moon and Renee D. Boss


30. Family Perspective of Necrotizing Enterocolitis


Jennifer Canvasser


31. The Role of Toll-Like Receptor Signaling in the Pathogenesis of NEC


Maame Efua Sampah and David J. Hackam


32. The Role of Growth Factor Signaling in the Development and Treatment of Necrotizing Enterocolitis


Rita D. Shelby, Terrence M. Rager, Barrett P. Cromeens, and Gail E. Besner


33. The Role of Platelet-Activating Factor in the Pathogenesis of Necrotizing Enterocolitis


Michael Caplan


34. The Role of Vascular Development in the Pathogenesis of Necrotizing Enterocolitis


Isabelle G. De Plaen, Elizabeth Managlia, and Xiaocai Yan


35. Bile Acids in the Pathogenesis of Necrotizing Enterocolitis


Melissa D. Halpern


36. Bacterial Communities in the Pathogenesis of Necrotizing Enterocolitis


Brigida Rusconi, Misty Good, and Barbara Warner


37. The Importance of Immune Cells in the Pathogenesis of NEC


Andres Gonzalez Salazar and David J. Hackam


38. The Role of Nitric Oxide Signaling in the Pathogenesis of Necrotizing Enterocolitis


Anatoly Grishin, Patrick T. Delaplain, Jin Wang, Michael Mallicote, Michelle Nguyen, Michael Philippe-Auguste, Christopher P. Gayer, and Henri R. Ford


39. The Silver Lining: The Small Intestinal Epithelial Barrier and Its Role in Necrotizing Enterocolitis


Mark R. Frey, Misty Good, and Steven J. McElroy


40. Innate and Adaptive Immune Dysfunction and Necrotizing Enterocolitis


Paula Osterhout, Christina S. Kim, and Erika C. Claud


41. Intestinal Immune Adaptation and Necrotizing Enterocolitis


Mathias W. Hornef


42. Advancements in Research on Necrotizing Enterocolitis Pathogenesis and Prevention Using Pigs


Douglas Burrin, Juan Marini, Murali Premkumar, Barbara Stoll, and Per Torp Sangild


43. Small Animal Models for the Study of Necrotizing Enterocolitis and "NEC-in-a-Dish"


Mark L. Kovler, Chhinder P. Sodhi, and David J. Hackam


44. Nutritional Considerations in Necrotizing Enterocolitis


Jae H. Kim


45. The Paneth Cell and Its Role in the Development of NEC


Brian A. Juber and Steven J. McElroy


46. Human Donor Milk and Necrotizing Enterocolitis


Maggie Meeks and Rachael Lamb


47. The Genetic Basis of NEC Susceptibility


Lovya George, Wei Yu, Alain Cuna, and Venkatesh Sampath


48. Anemia as a Modifiable Risk Factor for NEC


Ravi Mangal Patel


49. Lipids and Lipid Metabolism in Postnatal Gut Development and Risk of Intestinal Injury


Camilia R. Martin


50. Machine Learning in Necrotizing Enterocolitis: Challenges and Opportunities


Jennine Weller and David J. Hackam


51. Necrotizing Enterocolitis Risk from a Maternal-Fetal Medicine Perspective


Mark L. Kovler, Savannah Ireland, Angie C. Jelin, and Eric B. Jelin


52. Future Directions and Research Opportunities in NEC: The Top Ten Unanswered Questions and Top Five Areas of Research Focus


David J. Hackam


Index

Om forfatteren

David J. Hackam, MD, PhD, FACS.
Pediatric Surgeon-in-Chief and Co-Director, The Johns Hopkins Children's Center
Garrett Professor and Chief of Pediatric Surgery,
Professor of Surgery, Pediatrics, Cell Biology, and Genetic Medicine
Johns Hopkins University School of Medicine
Baltimore, Maryland , USA