Pathology of the Placenta

A Practical Guide

T. Yee Khong (Redaktør) ; Eoghan E. Mooney (Redaktør) ; Peter G. J. Nikkels (Redaktør) ; Terry K. Morgan (Redaktør) ; Sanne J. Gordijn (Redaktør)

This book provides a comprehensive resource on the pathology of the human singleton placenta. Agreed nomenclature, nosology, definitions and, where possible, thresholds for meaningful clinical corrections for lesions ideal for practical application in clinical practice are presented. Les mer
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Om boka

This book provides a comprehensive resource on the pathology of the human singleton placenta. Agreed nomenclature, nosology, definitions and, where possible, thresholds for meaningful clinical corrections for lesions ideal for practical application in clinical practice are presented. Evidence is also featured on relevant potential clinical correlations to aid the reader in deciding upon the most appropriate management strategy. Areas of current uncertainty are also covered for potential future research.

Pathology of the Placenta systematically describes placental pathology, and represents a valuable resource for practising and trainee pathologists, obstetricians, neonatologists and epidemiologists.

Fakta

Innholdsfortegnelse

Section 1. Background



Chapter 1. Introduction. An approach to placental pathology



Chapter 2. Placental Development with Expected Normal Gross and Microscopic Findings



Chapter 3. Indications for examining the placenta







Section 2. Gross examination


Chapter 4. Gross examination



Chapter 5. Placental Weight, Shape, and Gross Vascular Morphology







Section 3. Placental disc: Macroscopically Visible Lesions



Chapter 6. Infarction



Chapter 7. Intervillous thrombosis



Chapter 8. Massive perivillous fibrin deposition, maternal floor infarct



Chapter 9. Retroplacental haemorrhage, marginal haemorrhage



Chapter 10. Fetal Vascular Thrombosis



Chapter 11. Extravillous trophoblast cyst







Section 4. Placental disc: Microscopic Lesions



Chapter 12. Acute Chorioamnionitis



Chapter 13. Chorionic plate chronic inflammatory lesions including eosinophilic/T-cell chorionic vasculitis



Chapter 14. Maturity anomalies



Chapter 15. Distal villous hypoplasia



Chapter 16. Placental mesenchymal dysplasia



Chapter 17. Increased syncytial knot formation



Chapter 18. Persistence of cytotrophoblast



Chapter 19. Mineralization of trophoblast basement membrane



Chapter 20. Trophoblast and stroma: vacuolation - inherited disorder of metabolism



Chapter 21. Villous oedema



Chapter 22. Extramedullary haemopoiesis



Chapter 23. Intravillous haemorrhage



Chapter 24. Hypervascularity



Chapter 25. Fetal vascular malperfusion



Chapter 26. Presence of nucleated red blood cells



Chapter 27. Fetal vessels: malignancy



Chapter 28. Acute villitis



Chapter 29. Chronic villitis



Chapter 30. Chronic histiocytic intervillositis



Chapter 31. Intervillous space: infiltrates



Chapter 32. Pregnancy-induced uterine vascular remodelling and the pathophysiology of decidual vasculopathy



Chapter 33. Chronic deciduitis



Chapter 34. Basal plate myometrial fibres



Chapter 35. Basal plate laminar necrosis



Chapter 36. Retroplacental Haematoma/Haemorrhage (RPH)



Chapter 37. Miscellaneous Lesions of the Villous Parenchyma







Section 5. Amniochorial membranes: Macroscopically Visible Lesions



Chapter 38. Amniochorial membrane nodules



Chapter 39. Placental changes in amniotic band sequence, extra-amniotic and extramembranous pregnancy







Section 6. Amniochorial membranes: Microscopic Lesions



Chapter 40. Amnion Transport: Histologic Features



Chapter 41. Choriodecidual haemosiderin staining



Chapter 42. Laminar necrosis; membrane chorionic microcysts and chorion nodosum



Chapter 43. Decidual Vasculopathy



Chapter 44. Acute inflammation



Chapter 45. Chronic inflammation







Section 7. Umbilical cord



Chapter 46. Umbilical Cord Length



Chapter 47. Umbilical Cord coiling



Chapter 48. Cord knots and pseudo-knots



Chapter 49. Umbilical cord tumours



Chapter 50. Umbilical Cord Insertion abnormalities



Chapter 51. Embryonic remnants and pathology



Chapter 52. Single Umbilical Artery, Supernumerary Vessels, Segmental Thinning of the Umbilical Cord Vessels and Vascular calcifications in umbilical vessels



Chapter 53. Umbilical cord ulcer



Chapter 54. Umbilical vascular myonecrosis



Chapter 55. Inflammation







Section 8. Clinical correlation, reporting and frontiers



Chapter 56. Constellations of Pathology in the Placenta and How They Relate to Clinical Conditions.



Chapter 57. The Placental Pathology Report



Chapter 58. Frontiers

Om forfatteren

Dr. T. Yee Khong, MBChB, MD, MSc, FRCPath, FRCPA, FAMM, GAICD, is a Consultant Pathologist at SA Pathology, Women's and Children's Hospital, Adelaide, Australia. He qualified in medicine from University of Sheffield, UK and did his pathology training at St George's Hospital Medical School, London and John Radcliffe Hospital, Oxford, UK. He is Professor of Pathology and Obstetrics & Gynaecology, at the University of Adelaide and a former President of the Royal College of Pathologists of Australasia.
Dr. Eoghan Mooney, MBChB, MRCPI, FRCPath, FFPath (RCPI), was born in Dublin, Ireland, where he now lives and works. He is a graduate of the National University of Ireland (University College Dublin). Following pathology training in Dublin and in Duke University, North Carolina, USA he completed his Fellowship in Gynaecologic and Breast pathology in the Armed Forces Institute of Pathology, Washington DC. He has been a consultant pathologist for 17 years, based in the National Maternity Hospital and St Vincent's University Hospital and has published in the area of placental pathology for 20years.
Dr. Peter G.J. Nikkels, MD, PhD, is a staff member in the Department of Pathology, University Hospital Utrecht, the Netherlands. He qualified in medicine from Erasmus University Rotterdam, the Netherlands and did his pathology training at the Department of Pathology, University Hospital Groningen, the Netherlands where he became a consultant pathologist. He has published extensively in placental pathology.
Dr. Terry K. Morgan, MD, PhD, completed residency training, a surgical pathology fellowship and cytopathology fellowship at Stanford University Medical Center. He is Associate Professor of Pathology and Obstetrics & Gynecology, at the Oregon Health & Science University. He is the director of placental pathology and the focus of his research laboratory is to determine how abnormal blood flow to the placenta leads to common maternal pregnancy complications and fetal programming of adult onset disease in theirprogeny.
Dr. Sanne J Gordijn, MD, PhD, completed her residency training inUniversity of Groningen, the Netherlands and is a consultant in obstetrics witha special interest in perinatology. Her research interests are in perinatalautopsy, placental pathology and classification of perinatal mortality.