The Light-Cone 2016 conference, held in September 2016 in Lisbon, Portugal, belongs to a series of yearly Light-Cone meetings
that started in 1991. As its predecessors, this conference was guided by the objectives defined by the International Light
Cone Advisory Committee, namely to "advance research in quantum field theory, particularly light-cone quantization methods
applicable to the solution of physical problems". This volume compiles selected papers presented at the conference by experts
from all over the world, which describe recent progress in theoretical research, and new results and planned activities at
leading experimental facilities, with special emphasis on the physics of hadrons and nuclei.