Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 1

Jun Chen (Redaktør) ; Xiao-Ming Xu (Redaktør) ; Zao C. Xu (Redaktør) ; John H. Zhang (Redaktør)

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Les mer
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Om boka

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.



Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Fakta

Innholdsfortegnelse

Part I: General Morphological Assessments



1. Histopathological Assessments of Animal Models of Cerebral Ischemia

Ami P. Raval and Bingren Hu



2. Assessment of Cell Death: Apoptosis, Necrosis, or In Between

Tom Genetta, Ling Wei, and Shan Ping Yu



3. The Stereology and 3D Volume Analyses in Nervous Tissue

Rabindra P. Singh, Li Shen, and Feng C. Zhou



4. Assessments of Reactive Astrogliosis Following CNS Injuries

Candace L. Floyd



Part II: General Physiological Assessments



5. Physiological Assessment in Stroke Research

Casey Lee Hall, Osama Mohamad, Shan Ping Yu, and Ling Wei



6. EEG, Evoked Potential (EP), and Extracellular Single Unit Recordings In Vivo

Jie Wu



7. Intracellular Recording In Vivo and Patch-Clamp Recording on Brain Slices

Ping Deng and Zao C. Xu



8. Electrophysiological Evaluation of Synaptic Plasticity in Injured CNS

Xiaoming Jin



Part III: General Biochemical and Molecular Biological Assessments



9. Characterization of RNA

Marcel P. Van der Brug, Mar Matarin, and Taura L. Barr



10. MicroRNA Expression Profiling of Rat Blood and Brain Tissues: TaqMan Real-Time PCR MicroRNA Assays

Da-Zhi Liu, Bradley P. Ander, and Frank R. Sharp



11. Protein Analysis

Anthony Kian-Fong Liou and Jun Chen



12. Application of Zymographic Methods to Study Matrix Enzymes Following Traumatic Brain Injury

Lesley K. Harris, Raiford T. Black, Thomas M. Reeves, and Linda L. Phillips



Part IV: General Neurobehavioral Assessments



13. Rodent Behavioral Assessment in the Home Cage Using the SmartCageTM System

Xinmin Simon Xie, Jingxi Zhang , Bende Zou, James Xie, Jidong Fang, Nurulain T. Zaveri, and Taline V. Khroyan



14. Assessments of Cognitive Function Following Traumatic Brain Injury

Wendy M. Reid and Dong Sun



15. Assessment of Cognitive and Sensorimotor Deficits

Richard E. Hartman



16. Emotional and Anxiety Assessments in CNS Disorders

Zaorui Zhao and Junfang Wu



Part V: General Neuroimaging Assessments



17. Neuroimaging Assessment of Traumatic Brain Injury

Janna L. Harris and William M. Brooks



18. Imaging of Myelin by Coherent Anti-Stokes Raman Scattering Microscopy

Ji-Xin Cheng



Part VI: Subarachnoid Hemorrhage



19. Grading Scales for Subarachnoid Hemorrhage