Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 2

Jun Chen (Redaktør) ; Xiao-Ming Xu (Redaktør) ; Zao C. Xu (Redaktør) ; John H. Zhang (Redaktør)

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Les mer
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Vår pris: 2700,-

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Leveringstid: Sendes innen 21 dager

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The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.



Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Fakta

Innholdsfortegnelse

1. Introduction (Parts I-III)

R. Anne Stetler and Miguel A. Perez-Pinzon



Part I: Global Cerebral Ischemia (GCI)



2. Morphological Assessments of Global Cerebral Ischemia: Viable Cells

Peiying Li



3. Morphological Assessments of Global Cerebral Ischemia: Degenerated Cells

Peiying Li



4. Morphological Assessments of Global Cerebral Ischemia: Electron Microscopy

Irina S. Balan, Tibor Kristian, Chunli Liu, Andrew J. Saladino, and Bingren Hu



5. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: mRNA

R. Anne Stetler and Yu Gan



6. Biochemical and Molecular Biological Assessments of Global Cerebral Ischemia: Protein

Yu Gan and R. Anne Stetler



7. Neurobehavioral Assessments of Global Cerebral Ischemia

Pinar Kendigelen, Dandan Sun, and Pelin Cengiz<



8. Assessment of Neurogenesis in the Dentate Gyrus after Global or Focal Ischemia

Wei Liu and Jialing Liu



Part II: Focal Cerebral Ischemia (FCI)



9. Infarct Measurement in Focal Cerebral Ischemia: TTC Staining

Feng Zhang and Jun Chen



10. Morphological Assessments of Focal Cerebral Ischemia: White Matter Injury

Feng Zhang and Lyanne C. Schlichter



11. Blood Flow Reduction: Laser Doppler, 14C-IAP

Feng Zhang, Steven H. Graham, and Jun Chen



12. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: mRNA and MicroRNA

Yu Gan and R. Anne Stetler



13. Biochemical and Molecular Biological Assessments of Focal Cerebral Ischemia: Protein

R. Anne Stetler and Yu Gan



14. Assessments of Inflammation After Focal Cerebral Ischemia

Xiaoming Hu and Jun Chen



15. Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit

Yejie Shi and Dandan Sun



16. Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit

Yejie Shi and Dandan Sun



17. Assessment of Neurogenesis in Models of Focal Cerebral Ischemia

Feng-Yan Sun, Xiao Sun, Ji-Jiang Wang, Qiu-Wan Zhang, and Yong-Quan Wang



18. Assessment of Angiogenesis in Models of Focal Cerebral Ischemia

Hong Shi, Yanqin Gao, and Weimin Liang



Part III: Neonatal Hypoxia-Ischemia (NHI)



19. Morphological Assessments of Neonatal Hypoxia-Ischemia: In Situ Cell Degeneration

Changlian Zhu and Klas Blomgren



20. Morphological Assessments of Neonatal Hypoxia-Ischemia: White Matter Injury

Dianer Yang and Chia-Yi Kuan



21. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Cell Signaling

Changlian Zhu and Klas Blomgren



22. Biochemical and Molecular Biological Assessments of Neonatal Hypoxia-Ischemia: Inflammation

Xiaoming Hu and Jun Chen



23. Neurobehavioral Assessments of Neonatal Hypoxia-Ischemia

Masanori Iwai and Jun Chen



24. Assessment of Neurogenesis and White Matter Regeneration

Masanori Iwai, Hiroko Tajiri, Shiro Matsumoto, Hiroshi Mitsubuch, and Fumio Endo



Part IV: Traumatic Brain Injury (TBI)



25. Assessments for Traumatic Brain Injury: An Introduction

Kathryn E. Saatman



26. Morphological Assessments of Traumatic Brain Injury

Daniel van Bregt, Theresa Currier Thomas, Rachel D. Rowe, and Jonathan Lifshitz



27. Assessment of Cerebral Vascular Dysfunction after Traumatic Brain Injury

Douglas S. DeWitt and Donald S. Prough



28. Assessment of Membrane Permeability After Traumatic Brain Injury

Michelle C. LaPlaca and Marcus Chris Lessing



29. Assessment of Neurogenesis by BrdU Labeling After Traumatic Brain Injury

Jinhui Chen and Xiang Gao



30. Electrophysiological Approaches in Traumatic Brain Injury

Thomas M. Reeves and Beverly S. Colley



31. Biochemical and Molecular Biological Assessments of Traumatic Brain Injury

Coleen M. Atkins and Anthony Andrew Oliva, Jr.



32. Assessments of Oxidative Damage and Lipid Peroxidation after Traumatic Brain Injury and Spinal Cord Injury

Jeffrey M. Bosken, Juan A. Wang, and Edward D. Hall



33. Neurobehavioral Assessments of Traumatic Brain Injury

James W. Bales, Kristin Macfarlane, and C. Edward Dixon



34. Vestibular Assessments Following Traumatic Brain Injury

James W. Bales, Kristin Macfarlane, and C. Edward Dixon



Part V: Spinal Cord Injury (SCI)



35. Introduction on Assessments for Spinal Cord Injury

Theo Hagg



36. Morphological Assessments Following Spinal Cord Injury

Chandler L. Walker and Xiao-Ming Xu



37. Assessment of Lesion and Tissue Sparing Volumes Following Spinal Cord Injury

Lyn B. Jakeman



38. Retrograde Axonal Tract Tracing

Lingxiao Deng, Xiaofei Wang, Chandler L. Walker, Yiwen Ruan, and Xiao-Ming Xu



39. Anterograde Axonal Tract Tracing

Xiaofei Wang, Lingxiao Deng, and Xiao-Ming Xu



40. Assessments of Gliogenesis After Spinal Cord Injury

Drew L. Sellers and Philip J. Horner



41. Assessing Microvessels After Spinal Cord Injury

Theo Hagg, Richard L. Benton, Janelle M. Fassbender, and Scott R. Whittemore



42. Physiological Assessment of Spinal Cord Injury

Lisa B.E. Shields, Yi Ping Zhang, and Christopher B. Shields



43. Electrophysiological Assessment of Spinal Cord Function on Rodents Using tcMMEP and SSEP

Yi Ping Zhang, Lisa B.E. Shields, and Christopher B. Shields



44. Operant Conditioning of Spinal Cord Reflexes in Rats

Xiang Yang Chen and Jonathan R. Wolpaw



45. Cellular and Molecular Biological Assessments of Inflammation and Autoimmunity After Spinal Cord Injury

Yi Zhang, Daniel P. Ankeny, and Phillip G. Popovich



46. Neurobehavioral Assessments of Spinal Cord Injury

Jed S. Shumsky and John D. Houle



47. Basso, Beattie, and Bresnahan (BBB) Scale Locomotor Assessment Following Spinal Cord Injury and Its Utility as a Criterion for Other Assessments

Darlene A. Burke and David S.K. Magnuson



48. High Speed Video Recording Used for the Analysis of Hand Shaping in Over Ground Walking, Cylinder Exploration, Skilled Reaching, and Rung Walking in Rats

Ian Q. Whishaw and Lori-Ann Sacrey



49. Automated Gait Analysis Following Spinal Cord Injury

Jason E. Beare, Johnny R. Morehouse, David S.K. Magnuson, and Scott R. Whittemore



50. Forelimb Functional Assessments of Rats and Mice After Cervical Spinal Cord Injury

Stephen M. Onifer



51. Swimming as an Assessment of Hindlimb Function in Animals with Traumatic Spinal Cord Injury

Edward H. Brown, Johnny R. Morehouse, and David S.K. Magnuson



52. Neuroimaging Assessment of Spinal Cord Injury in Rodents

Mehmet Bilgen